Diagram showing Hippocampus, an area affected by Alzheimer’s Disease (credits Appendix A)
(1) The Amyloid Cascade Hypothesis does not appear to explain all cases of Alzheimer’s Disease particularly when this is late in onset.
(2) Tau gene mutations are described as leading to Frontotemporal Dementia rather than Alzheimer’s Type Dementia
(3) A dual pathway is hypothesised which describes processes upstream to the Amyloid deposition and tau phosphorylation and which influence both
(4) Small and Duff identify APOE4, GSK and the Retromer sorting pathway as three examples of upstream drivers
(5) When Amyloid deposition is absent or minimal but the other elements are present this has implications for Amyloid reducing strategies
Appendix A – Credits
Picture by FG Designs. Creative Commons License.
Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.
TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.
Responses: If you have any comments, you can leave them below or alternatively e-mail email@example.com.
Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.
Conflicts of Interest: *For potential conflicts of interest please see the About section.