I undertook a brief search of medline using the search term “vps35 and Alzheimer*” which returned 27 papers (2005-2017). Interestingly the first paper is by Small and colleagues. (relevant to Small and Duffy’s Dual Pathway Hypothesis of Alzheimer’s Disease). In this paper, the researchers hypothesise a mechanism of action for an implicated gene/protein. The researchers then analyse gene expression of candidate genes in the Hippocampus and Entorhinal Cortex in the brains of people who had experienced Alzheimer’s Disease and in controls. They supported this data with cell cultures investigating the role of the Retromer complex and more specifically VPs35. They find evidence that VPs35 alters the processing of ABeta peptide levels in the cell cultures. This provides a firm foundation for one aspect of the Dual Pathway Hypothesis.
Twitter: You can follow ‘The Amazing World of Psychiatry’ Twitter by clicking on this link.
TAWOP Channel: You can follow the TAWOP Channel on YouTube by clicking on this link.
Responses: If you have any comments, you can leave them below or alternatively e-mail email@example.com.
Disclaimer: The comments made here represent the opinions of the author and do not represent the profession or any body/organisation. The comments made here are not meant as a source of medical advice and those seeking medical advice are advised to consult with their own doctor. The author is not responsible for the contents of any external sites that are linked to in this blog.
Conflicts of Interest: *For potential conflicts of interest please see the About section.